- The title of this episode is a reference to an earlier episode in the series Season 1's "Sacred Cow."
- This is the first episode where comedy partners Keegan-Michael Key and Jordan Peele guest star together despite appearing separately in many episodes.
- Final episode where Jordan Peele voices characters prior to his retirement from acting in 2018.
- There was some confusion over this episode's title as Loren Bouchard stated in a January 2016 interview in NJ Tech Reviews that the episode's title is "Second Couch", this might have been a typographical error as the official title was confirmed to be "Sacred Couch" by Fox's official press release.
- A total of 2.64 million households watched this episode.
- After Louise sabotages the couch, Bob can be seen sitting down on the floor reading Open Toe Living, a magazine previously mentioned in "The Runway Club."
- The draft beers on sale at The Ear Drum are; Bigsley's ($7), Pale Rock ($7), St Leon's ($8), Wellsley's ($8) and Dark Moon ($9).
- Posters on the walls at The Ear Drum include; Bad Hair Day (from "Purple Rain-Union"), Perfume, I Don't Do Mondays (ironically playing on a Monday), Crotchwaffle and the Urine Cakes, That Just Happened, The Two Pump Champs, Doted Swiss, and Soup or Chunk.
- A "Ghost Boy" graffiti tag (from "The Land Ship") can be seen on the wall by the old train depot where the Couch Burners attempt to burn the Belchers old couch.
- In the flashback to Tina teething on the couch Linda appears to be pregnant (presumably with Gene).
- Snacks in the Belchers cupboard include; Chippy Chomps and Shim Shams, both previously seen/mentioned in the series.
- Linda's line "you Kevorkian-ed it" refers to the pathologist and euthanasia advocate Dr. Jack Kevorkian who assisted the suicides of at least 130 of his patients.
- Gene mentions he knows an upholsterer on Cape Cod, Gene's voice actor Eugene Mirman currently resides on Cape Cod in the town of Falmouth.