- The title of this episode is a reference to the musical number featured in Season 4's "Wharf Horse", "Nice Things Are Nice."
- A poster in Nurse Liz's office has a picture of a cat with an oral thermometer in its mouth. The text underneath says "Take My Tem-purr-ature!"
- Books seen in the library include; Your Parents' Changing Bodies, Careers in Skateboarding, Pimples Made Simple, Let's Talk Testicles and Everyone Has a Tushy, the latter was the title of an episode of Dr. Katz, Professional Therapist which also featured the book.
- First appearance of Marshmallow since Season 4's I Get Psy-chic Out of You.
- First speaking appearances of Regular Sized Rudy and Andy and Ollie Pesto in Season 6.
- Superlice is a reference to Superbugs or Anti-Microbial Resistance micro-organisms developing resistance to antibiotic drugs, making them incurable.
- A total of 2.28 million households watched this episode.
- Louise referring to there being a tunnel behind the poster is a reference to the movie The Shawshank Redemption, a similar reference was made in "Bob Fires the Kids" where Mickey covers up a tunnel he's digging to First Oceanside Savings Bank with a poster of the movie Big.
- One of the letters Mike delivers to the restaurant has a "past due" stamp on it, a reference to the family often not being able to pay rent or bills on time.
- The Nurse's office appears different to how it appeared in "The Frond Files", although the scene in which it featured is not considered part of the series canon.
- The movie Linda refers to starring Kelly McGillis and Harrison Ford is Witness.
- In a promotional image for this episode released by Fox, Tammy's hat is colored beige, it is purple in the final episode. Possibly to differentiate from Linda's sunhat as seen in a few episodes which appears to be similar in color to Tammy's.
- When Linda first sits on the new bar stools, her apron's pocket is over her left leg rather than her right.
- Zeke expresses a desire not to have his head shaved in this episode but in "Bad Tina" he stated that he wanted to shave his head when he turned 14.
- Gene states that he hasn't been bald since he was a baby but in a cutaway in "Beefsquatch" he is seen with a bald head during one of his "this is me, now" phases where he appears as a monk, although he could have just been wearing a bald cap.
- Regular Sized Rudy runs out of inhalant but his condition doesn't start to deteriorate as the episode goes on as it did when he didn't use his inhaler in "Carpe Museum."